PPIs may lead to kidney problems by prematurely aging blood vessels

May 18th, 2016

Recent research from the Houston Methodist Research Institute has discovered one way that proton pump inhibitors (PPIs) may lead to an increased risk of severe side effects, including kidney problems. Doctor John P. Cooke led a research team that discovered PPIs, which include common over-the-counter acid reflux drugs Nexium and Prevacid, prematurely age the endothelial cells that line the interior of blood vessels.

Dr. Cooke’s research may be the first to better understand the reason behind the conclusion of several other studies, which is that Prevacid and Nexium lead to an increased risk of kidney disease. Dr. Cooke explained in his conclusions that, when healthy, endothelial cells create a smooth coating that prevents blood from sticking. But when unhealthy and older, they become more like Velcro, collecting blood elements which could form blockages.

PPIs such as Nexium and Prevacid are among the most common drugs in the world, with approximately 15 million Americans receiving prescriptions for them and countless more buying them over-the-counter. PPI manufacturers could face lawsuits from patients who took the drugs and suffered kidney failure.


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