Actos Side Effects

The Food and Drug Administration has warned that the use of the diabetes drug Actos for more than one year can increase a patient’s risk of developing bladder cancer. The agency has also warned that Actos can increase the risk of other side effects, including congestive heart failure, liver injury and hepatitis.

The FDA’s warning about Actos stated that patients who took the drug for over a year were at least 40% more likely to develop bladder cancer. Other data from researchers in Europe found that Actos increased the risk of bladder cancer compared to other diabetes medications regardless of the length of use. Health officials in Germany and France stopped sales of Actos in those countries due to these findings about the side effects of Actos.

In May 2007, the Food and Drug Administration asked Takeda Pharmaceuticals to add a “black-box” warning to its diabetes drug Actos after it was linked to an increased risk of congestive heart failure. The black-box warning is the strongest kind issued by the FDA. A study conducted by the FDA in 2002 suggested that TZDs could cause fluid retention, which could cause or worsen congestive heart failure.

The FDA also warns about the risk of liver injury and hepatitis in patients taking Actos. The agency has received reports of patients whose liver enzymes were three times the normal level. In some cases, these patients experienced liver failure. A 2002 study in the Annals of Internal Medicine also reported a link between Actos and liver injuries.

If you or a loved one have suffered Actos side effects such as bladder cancer, heart problems or liver injury, you may wish to consider filing a lawsuit. To speak with an Actos attorney, contact the law office of Hissey Kientz by calling toll-free at (866) 275-4454, or by filling out a free case evaluation form (top right of this page).

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